Search results for "Antitissue transglutaminase antibodie"

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Guinea pig transglutaminase immunolinked assay does not predict coeliac disease in patients with chronic liver disease

2001

BACKGROUND—It has been suggested that serological screening for coeliac disease (CD) should be performed in patients with chronic unexplained hypertransaminasaemia. AIMS—To evaluate the specificity for CD diagnosis of serum IgA antitissue transglutaminase (tTG) determination in consecutive patients with chronic hypertransaminasaemia using the most widely utilised ELISA based on tTG from guinea pig as the antigen. PATIENTS AND METHODS—We studied 98 patients with chronic hypertransaminasaemia, evaluated for the first time in a hepatology clinic. Serum anti-tTG and antiendomysial (EmA) assays were performed. Patients positive for EmA and/or anti-tTG were proposed for intestinal biopsy. Finally…

AdultLiver CirrhosisMalemedicine.medical_specialtySettore MED/09 - Medicina InternaCirrhosisAdolescentHepatitis Viral HumanTissue transglutaminaseGuinea PigsAutoimmunityEnzyme-Linked Immunosorbent AssayChronic liver diseaseSensitivity and SpecificityCoeliac diseaseArticleStatistics NonparametricAntiendomysial antibodieIntestinal histologySerologyLiver diseaseIntestinal mucosaPredictive Value of TestsInternal medicinemedicineAnimalsHumansFalse Positive ReactionsTransaminasesAutoantibodiesTransglutaminasesCoeliac diseasebiologybusiness.industryAntitissue transglutaminase antibodieGastroenterologyHepatologyMiddle Agedmedicine.diseaseImmunoglobulin ACeliac DiseaseImmunologyChronic Diseasebiology.proteinLinear ModelsFemalebusinessLiver disease

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